Department of Forest Genetics and Plant PhysiologyThe Department of forest genetics and plant physiology is part of Umeå Plant Science Centre (UPSC, https://www.upsc.se/) which is a centre of excellence for experimental plant research and forest biotechnology in Northern Sweden. Our mission is to perform excellent and innovative basic research and generate knowledge that benefits forestry, agriculture, environment and society. We work across a wide range of disciplines in plant science reaching from cell biology to ecophysiology and from basic research to industrial applications. Our common goal is to understand the plants' ability to grow, adapt and acclimate to a changing world and how we can breed better plants.Om jobbetThe project focuses on studying the roles of the CSN5A and CSN5B subunits of the COP9 signalosome (CSN complex) in regulating adventitious root development.The CSN is an evolutionarily conserved multiprotein complex that regulates protein degradation. The complex is composed of eight subunits, CSN1-CSN8. The CSN5 subunit exhibits catalytic activity, specifically deneddylation of the CULLIN subunits. Certain plant species have duplicated the CSN5 (CSN5A; CSN5B) and CSN6 (CSN6A; CSN6B) subunits, leading to the presence of 4 different multiprotein complex types. The objectives are to analyse the structure of the different complexes, which should help in understanding their respective function. The various complexes will be purified from yeast expressing tagged versions of the subunits and from Arabidopsis double mutants in which only one of the four complexes is present. The structural analysis will be performed in collaboration with CryoEM facility.As a researcher, you will purify the different CSN complexes from yeast and the double mutants and analyze…Forskare, mikrobiologiCell- och molekylärbiologer m.fl.
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